Christos S Mantzoros Selected Research

metreleptin

1/2022	Metreleptin for the treatment of lipodystrophy: leading the way among novel therapeutics for this unmet clinical need.
1/2021	Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings.
1/2019	Circulating levels of the components of the GH/IGF-1/IGFBPs axis total and intact IGF-binding proteins (IGFBP) 3 and IGFBP 4 and total IGFBP 5, as well as PAPPA, PAPPA2 and Stanniocalcin-2 levels are not altered in response to energy deprivation and/or metreleptin administration in humans.
1/2015	From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century.
11/2014	The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea.
2/2013	Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia.
9/2011	Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women.
8/2011	Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.
7/2011	Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study.
6/2011	Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance.

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Christos S Mantzoros Research Topics

Disease

94	Obesity 12/2022 - 03/2002
86	Insulin Resistance 03/2022 - 05/2002
38	Neoplasms (Cancer) 01/2021 - 01/2002
32	Type 2 Diabetes Mellitus (MODY) 09/2022 - 03/2005
31	Body Weight (Weight, Body) 11/2022 - 05/2002
31	Weight Loss (Weight Reduction) 01/2022 - 09/2003
28	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 02/2003
28	Non-alcoholic Fatty Liver Disease 01/2022 - 06/2012
22	Inflammation (Inflammations) 03/2022 - 08/2005
22	Lipodystrophy 01/2022 - 02/2003
22	Amenorrhea 12/2020 - 03/2002
20	Cardiovascular Diseases (Cardiovascular Disease) 08/2022 - 08/2006
15	Overweight 03/2022 - 10/2003
11	Carcinogenesis 01/2019 - 01/2002
10	Weight Gain 09/2022 - 11/2007
10	Colorectal Neoplasms (Colorectal Cancer) 04/2016 - 11/2005
9	Fibrosis (Cirrhosis) 06/2021 - 01/2015
8	Diabetes Mellitus 01/2021 - 01/2008
8	Anorexia Nervosa 07/2012 - 07/2002
7	Hyperlipidemias (Hyperlipidemia) 01/2022 - 06/2004
7	Glucose Intolerance 06/2013 - 06/2006
7	Starvation 04/2013 - 05/2003
6	Atherosclerosis 03/2022 - 08/2005
6	Fatty Liver 01/2022 - 01/2015
6	Abdominal Obesity 09/2016 - 10/2003
6	Dyslipidemias (Dyslipidemia) 01/2016 - 08/2004
6	Hyperinsulinism (Hyperinsulinemia) 01/2016 - 03/2004
5	COVID-19 01/2022 - 01/2020
5	Thyroid Neoplasms (Thyroid Cancer) 01/2021 - 12/2011
5	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2007
5	Colonic Neoplasms (Colon Cancer) 12/2013 - 01/2007
5	Feeding and Eating Disorders (Eating Disorder) 01/2006 - 03/2002
4	Metabolic Diseases (Metabolic Disease) 01/2022 - 10/2016
4	Liver Cirrhosis (Hepatic Cirrhosis) 06/2021 - 12/2017
4	Necrosis 10/2020 - 02/2010
4	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2020 - 04/2004
4	HIV Infections (HIV Infection) 02/2013 - 03/2003
3	Hypertension (High Blood Pressure) 03/2022 - 11/2011
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2022 - 01/2016
3	Thrombosis (Thrombus) 01/2022 - 10/2018
3	Hyperglycemia 12/2021 - 06/2014

Drug/Important Bio-Agent (IBA)

102	LeptinIBA 03/2022 - 03/2002
85	AdiponectinIBA 01/2021 - 02/2003
44	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2003
41	Insulin (Novolin)FDA Link 09/2022 - 05/2002
33	Hormones (Hormone)IBA 03/2020 - 01/2002
26	AdipokinesIBA 03/2022 - 06/2003
25	LipidsIBA 01/2022 - 10/2003
15	Adiponectin ReceptorsIBA 08/2012 - 01/2004
14	Biomarkers (Surrogate Marker)IBA 03/2020 - 03/2007
13	ResistinIBA 03/2022 - 10/2003
11	metreleptinIBA 01/2022 - 03/2010
11	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2021 - 09/2013
11	FollistatinIBA 01/2021 - 01/2016
11	recombinant methionyl human leptinIBA 01/2016 - 05/2003
10	CholesterolIBA 06/2021 - 09/2005
10	Triglycerides (Triacylglycerol)IBA 01/2021 - 02/2003
9	CytokinesIBA 01/2022 - 09/2003
9	Interleukin-6 (Interleukin 6)IBA 10/2020 - 09/2003
9	Proteins (Proteins, Gene)FDA Link 03/2020 - 02/2003
9	Messenger RNA (mRNA)IBA 12/2012 - 10/2003
8	Coffee FDA Link 01/2022 - 03/2008
8	Liraglutide FDA Link 01/2022 - 01/2016
7	Activins (Activin)IBA 01/2021 - 01/2018
7	HDL CholesterolIBA 10/2020 - 08/2005
7	Insulin-Like Growth Factor I (IGF-1)IBA 02/2019 - 05/2003
6	C-Reactive ProteinIBA 10/2020 - 03/2005
6	Insulin-Like Growth Factor Binding ProteinsIBA 01/2020 - 07/2008
6	Leptin ReceptorsIBA 01/2016 - 05/2002
6	Metformin (Glucophage)FDA LinkGeneric 01/2016 - 10/2011
6	Therapeutic UsesIBA 01/2015 - 03/2005
5	Hypoglycemic Agents (Hypoglycemics)IBA 09/2022 - 01/2008
5	Lipoproteins (Lipoprotein)IBA 01/2022 - 08/2005
5	Biological ProductsIBA 01/2021 - 07/2002
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 03/2015
5	Vitamin E FDA LinkGeneric 10/2020 - 06/2003
5	Pioglitazone (Actos)FDA Link 10/2020 - 03/2005
5	Insulin-Like PeptidesIBA 03/2020 - 07/2005
5	alpha-2-HS-GlycoproteinIBA 01/2016 - 09/2011
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 04/2008
4	Caffeine (No Doz)FDA LinkGeneric 01/2022 - 03/2008
4	EnzymesIBA 01/2022 - 02/2007
4	lorcaserinIBA 01/2022 - 10/2016
4	Peptides (Polypeptides)IBA 01/2021 - 10/2004
4	HDL LipoproteinsIBA 10/2020 - 02/2003
4	Nonesterified Fatty Acids (NEFA)IBA 10/2020 - 05/2002
4	ThiazolidinedionesIBA 09/2020 - 01/2007
4	AntioxidantsIBA 01/2020 - 01/2012
4	activin AIBA 01/2020 - 10/2016
4	Carrier Proteins (Binding Protein)IBA 02/2019 - 01/2002
4	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2019 - 10/2003
4	GhrelinIBA 07/2016 - 04/2006
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2005 - 09/2003

Therapy/Procedure

31	Therapeutics 01/2022 - 01/2002
13	Highly Active Antiretroviral Therapy (HAART) 01/2022 - 02/2003
12	Bariatric Surgery 01/2020 - 08/2012
5	Drug Therapy (Chemotherapy) 12/2022 - 01/2018
4	Mediterranean Diet 01/2022 - 03/2009
3	Caloric Restriction 01/2022 - 09/2004
3	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2022 - 02/2006